Jessica Wagner Selected Research

TIC10 compound

1/2018	Anti-tumor effects of ONC201 in combination with VEGF-inhibitors significantly impacts colorectal cancer growth and survival in vivo through complementary non-overlapping mechanisms.
1/2018	Dose intensification of TRAIL-inducing ONC201 inhibits metastasis and promotes intratumoral NK cell recruitment.
10/2017	Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP.
10/2017	Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212.
10/2017	ONC201: a new treatment option being tested clinically for recurrent glioblastoma.
1/2017	ONC201 Demonstrates Antitumor Effects in Both Triple-Negative and Non-Triple-Negative Breast Cancers through TRAIL-Dependent and TRAIL-Independent Mechanisms.
11/2016	Discovery and clinical introduction of first-in-class imipridone ONC201.
12/2014	The angular structure of ONC201, a TRAIL pathway-inducing compound, determines its potent anti-cancer activity.

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Jessica Wagner Research Topics

Disease

13	Neoplasms (Cancer) 05/2024 - 12/2014
3	Brain Neoplasms (Brain Tumor) 05/2024 - 11/2020
3	Hematologic Neoplasms (Hematological Malignancy) 11/2020 - 11/2016
2	Alzheimer Disease (Alzheimer's Disease) 12/2022 - 01/2022
2	Neoplasm Metastasis (Metastasis) 01/2021 - 01/2018
2	Melanoma (Melanoma, Malignant) 10/2017 - 10/2017
1	Starvation 11/2023
1	Cognitive Dysfunction 12/2022
1	Amyloid Plaque 01/2022
1	Adenocarcinoma 01/2021
1	Carcinogenesis 01/2021
1	Syphilis 01/2021
1	Urethritis 10/2020
1	Gonorrhea 10/2020
1	Colorectal Neoplasms (Colorectal Cancer) 01/2018
1	Liver Neoplasms (Liver Cancer) 10/2017
1	Pancreatic Neoplasms (Pancreatic Cancer) 10/2017
1	Skin Neoplasms (Skin Cancer) 10/2017
1	Glioblastoma (Glioblastoma Multiforme) 10/2017
1	Vascular Calcification 01/2017
1	Breast Neoplasms (Breast Cancer) 01/2017
1	Triple Negative Breast Neoplasms 01/2017
1	Chronic Kidney Failure (Chronic Renal Failure) 12/2015
1	Hypertension (High Blood Pressure) 06/2015
1	Body Weight (Weight, Body) 06/2015
1	Brain Death (Brain Dead) 05/2005

Drug/Important Bio-Agent (IBA)

8	TIC10 compoundIBA 01/2018 - 12/2014
5	AntigensIBA 05/2024 - 11/2020
4	Proteins (Proteins, Gene)FDA Link 05/2024 - 01/2021
3	Chimeric Antigen ReceptorsIBA 05/2024 - 11/2020
2	Protein Isoforms (Isoforms)IBA 05/2024 - 01/2024
2	Fibronectins (Fibronectin)IBA 05/2024 - 01/2021
2	RNA (Ribonucleic Acid)IBA 05/2024 - 01/2024
2	ONC212IBA 10/2017 - 10/2017
1	CytokinesIBA 11/2023
1	Interleukin-10 ReceptorsIBA 11/2023
1	Cytokine Receptors (Cytokine Receptor)IBA 11/2023
1	Amyloid (Amyloid Fibrils)IBA 12/2022
1	Amyloid beta-PeptidesIBA 01/2022
1	CollagenIBA 01/2021
1	NetrinsIBA 01/2021
1	Neutralizing AntibodiesIBA 01/2021
1	Methamphetamine (Desoxyn)FDA LinkGeneric 01/2021
1	Anti-Bacterial Agents (Antibiotics)IBA 10/2020
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2018
1	Bevacizumab (Avastin)FDA Link 01/2018
1	Antineoplastic Agents (Antineoplastics)IBA 01/2018
1	tyrphostin AG 1024IBA 10/2017
1	Endoplasmic Reticulum Chaperone BiPIBA 10/2017
1	Fluorouracil (Carac)FDA LinkGeneric 10/2017
1	Irinotecan (Camptosar)FDA LinkGeneric 10/2017
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 10/2017
1	CrizotinibIBA 10/2017
1	ONC206IBA 10/2017
1	MagnesiumIBA 01/2017
1	TNF-Related Apoptosis-Inducing LigandIBA 01/2017
1	LigandsIBA 11/2016
1	Phosphates (Orthophosphate)IBA 12/2015
1	SodiumIBA 06/2015
1	PotassiumIBA 06/2015
1	Dietary SodiumIBA 06/2015

Therapy/Procedure

8	Therapeutics 01/2021 - 12/2015
2	Immunotherapy 05/2024 - 01/2024
2	Peritoneal Dialysis 01/2017 - 12/2015
1	Surgical Amputation (Amputations) 01/2021
1	Nutritional Support (Artificial Feeding) 01/2021
1	Critical Care (Surgical Intensive Care) 05/2005